ارزیابی خطر سرطان‌زایی و غیر سرطان‌زایی مواجهه با استرهای فتالات از طریق مصرف آب‌های بطری شده در طول زمان نگهداری

Background and Objectives: Bottles for packaging drinking water represent one of the most popular uses of plastic and polymer additives. Recently, public concerns related to possibility of exposure to chemicals through the consumption of polyethylene terephthalate bottled water has caused great concern to consumers. Phthalate esters, as a class of these compounds, are often classified as endocrine disruptors and one of them is a possible carcinogen for human. The aim of this study was to determine the concentrations of phthalates in bottled water and to calculate the health risk of phthalates intake via consumption of bottled waters. Materials and Method: After purchasing, samples were immediately stored according to the recommended conditions (25 ºC, dark place) given on the bottle label. Migration of phthalates was investigated in PET-bottled water at different time intervals using gas chromatography–mass spectroscopy. Therefore, a phthalate exposure assessment was performed to characterize their risk to the consumer’s health via a calculated hazard quotient (HQ). Results: It seems that the duration of storage affects phthalate migration. Total increases of DEHP (811.8%), DBP (2545.2%), and BBP (832%) were observed at 12 months over the initial level before storage (bottled water immediately after production) but the level of phthalates in bottled water was always very low (<EPA:6 μg/L). Non-carcinogenic risk assessment from exposure to phthalate via consumption of bottled water was negligible in all of the subject groups (HQ<1). Furthermore, a little excess cancer risk of 9.9×10-7 for bis (2-ethylhexyl) phthalate (DEHP) was observed.Conclusion: The research showed that the concentration of phthalates in PET-bottled water was extremely low. Consequently, based on the risk assessment results, bottled waters regarding existence of safe for consumers and they phthalates are not considered as public health issue for consumers as phthalates does not have any risk exposure for the consumers.